HHMI - Howard Hughes Medical Institute

HHMI is pledging $2 billion to achieve goals that will benefit us all. Learn more about our strategy to influence academic science at key career stages. 

A mutated protein causes the genetic disease cystic fibrosis. Now, researchers have solved the structure of the protein and how certain drugs bind to it, unveiling their mode of action.

For the first time, scientists have shown exactly how a fly brain creates a mental map of the body’s movement through the world.

Scientists solved the structure of a large human protein complex and uncovered some unexpected differences between people and yeast. The structure could guide the development of drugs to treat diseases that arise when this complex malfunctions.

A cell-by-cell map of the mouse iris lays the foundation to study eye disorders and engineer cell therapies to replace damaged eye tissue.

Codetta, a new computational method for predicting genetic codes, could reveal insights into how some organisms have modified a code once thought to be universal.

Janelia’s COSEM Project Team has created a set of tools to make annotated 3D images of cells, showing the relationships between different organelles.

HHMI Trustee David Julius of the University of California, San Francisco, and HHMI Investigator Ardem Patapoutian of Scripps Research won the prize for their discoveries of receptors for temperature and touch.

The scientists come from 21 US institutions and will join a community of Investigators who are tackling some of the most challenging problems in biomedical research.